Vitamin d and simvastatin drug interactions ehealthme. Simvastatin and cannabis drug interactions a study of fda. This study is created by ehealthme based on reports of 20 people who take simvastatin and cannabis from food and drug administration fda, and is updated regularly. Dec 11, 2014 the maximum recommended dose for simvastatin in conjunction with amlodipine or diltiazem is now 20 mgday a full updated listing of all the interactions is provided in the table below. Az guide to drugherbvitamin interactions revised and.
Simvastatin should not be taken by people taking the medicines gemfibrozil, ciclosporin, danazol, idelalisib or nefazadone. The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking drug drug interaction, food, beverages, dietary supplements the person is consuming drug nutrient food interaction or another disease the person has drug disease interaction. Drug interactions are reported among people who take levothyroxine sodium and simvastatin together. Once absorbed into the portal venous system, while all statins. Table 1 summarizes several possible interactions of drugs with. Fooddrug interactions what you eat and drink can affect the way your medicines work. Niacin simvastatin interactions grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. For example, taking alcohol with the antibiotic metronidazole can cause flushing, headache, palpitations, and nausea and vomiting. In case of overdose, get medical help or contact a poison control center immediately. Eating grapefruit can inhibit cytochrome p450 34a, slowing metabolism of some drugs eg, amiodarone. Provides a summary of interactions with vitamins, herbs, and food. Atorvastatin interacts with grapefruit and its juice. Drug nutrient interactions involve changes to a drug caused by a nutrient, or changes to a nutrient as a result of the drug.
The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug. Simvastatin and ibuprofen drug interactions a study of. A clinicians guide to statin drugdrug interactions. Although many people do not consider alcohol a nutrient, it affects body processes and interacts with many drugs. Drug nutrient interactions are defined as physical, chemical, physiologic, or pathophysiologic relationships between a drug and a nutrient, and typically involve multiple factors 3,4. Niacin, warfarin, and fibrates are among the drugs that can potentially interact with simvastatin. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is.
Zocor simvastatin side effects, dosage, interactions. Oct 17, 2010 the effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking drug drug interaction, food, beverages, dietary supplements the person is consuming drug nutrient food interaction or another disease the person has drug disease interaction. When the way a medicine works is affected by food and drinks this is called a fooddrug interaction. It is important to know if you need to avoid any food, herbs, or alcohol when taking simvastatin. Adverse drug reactions and medication errors are all potential consequences of polypharmacy. Grapefruit juice can significantly increase the blood levels of simvastatin. Do not drink more than 1 quart of grapefruit juice daily. Simvastatin interactions bnf content published by nice. A few of the drugs that can potentially interact with simvastatin include gemfibrozil, danazol, amiodarone, and digoxin. The recommended dose range of simvastatin is 10 mg to 40 mg, and it is administered once daily in the evening with or without food. This study is created by ehealthme based on reports of 7,286 people who take levothyroxine sodium and simvastatin from the food and drug administration fda, and is updated regularly. Aha statement on drugdrug interactions with statins. Drug interactions can be caused by prescription and overthecounter medications, herbal products or vitamins, foods, diseases, and genetics family history.
Doctors or pharmacists can answer questions about possible alcohol and drug interactions. Levothyroxine sodium and simvastatin drug interactions. Simvastatin interaction with food, herbs and alcohol. Simvastatin oral interactions with other medication. Mar 31, 2014 simvastatin was most commonly prescribed and simvastatin drug coprescription predominated, especially at discharge. If the client is taking a drug or medication that isnt on this list, check the food medications interactions book for possible side effects. Here, consumer reports lists food and drug interactions that you need to know about to stay safe. Drug interactions are reported among people who take vitamin d and simvastatin together. Nearly a quarter of all adults over age 40 take medication to treat high cholesterol, and most often, its a statin drug. Some medicines should not be taken with simvastatin. Prima health, herb contraindications and drug interac tions. Drugs can influence food intake, nutrient digestion, absorption, distribution, metabolism to active forms, function, catabolism and excretion 5, 6.
Interactions between simvastatin oral and avoidgrapefruit. Foods can enhance, delay, or decrease drug absorption. Jun 30, 2015 a half grapefruit is a great way to start the day unless youre taking a cholesterollowering statin such as atorvastatin lipitor or simvastatin zocor. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary. Grapefruit interferes with your bodys metabolism of atorvastatin lipitor, simvastatin zocor and lovastatin altoprev, mevacor, so your intended dose might not be accurate. Look up a drug to see which other drugs it interacts with and how serious those interactions are. Simvastatin interaction with food, herbs and alcohol it is important to know how to take the medication to avoid the drug food interaction. Usually, the starting dose is 10 or 20 mg once a day, in the evening. This emedtv page explains how drug interactions with simvastatin can raise your risk of serious muscle problems such as myopathy, among other things. Drug interactions with simvastatin drugs home page. This study is created by ehealthme based on reports of 5,187 people who take simvastatin and ibuprofen from food and drug administration fda, and is updated regularly. Given interaction potential between simvastatin and protease inhibitors, consider avoiding efavirenz and simvastatin in case patients antiretroviral regimen is changed and simvastatin is not changed to another statin. Atorvastatin interaction with food, herbs and alcohol.
See what the interactions are and for which people. Drug interactions drugs merck manuals consumer version. Nutrientdrug interactions nutritional disorders merck. The book starts the reader out with some basic concepts of pharmacy, moves on through drug biopharmaceutics, food drug interactions and metabolism. A new book from aarp offers dietary guidance on food drug interactions. Zocor simvastatin tablets food and drug administration. Statins can lower heart disease risk dramatically, but certain cautions apply. Broadway books, az guide to drugherbvitamin interactions.
Evidence of drugnutrient interactions with chronic use of. There is 1 alcoholfood lifestyle interaction with ezetimibe simvastatin. Always read the package insert to identify the drug interactions specific to the statin you are taking, whether it is crestor rosuvastatin, lescol fluvastatin, lipitor atorvastatin, mevacor lovastatin, pravachol pravastatin, or zocor simvastatin. Niacinsimvastatin side effects, dosage, interactions. Examples of statins available include atorvastatin lipitor, fluvastatin lescol, lovastatin mevacor, altocor, pravastatin pravachol, pitavastatin livalo, simvastatin zocor, and rosuvastatin crestor. The az guide to drug herbvitamin interactions is an essential resource to understanding the interactions that may affect your health. The exposure to all potential statin drug interactions was similar at hospital admission 26. Drug nutrient interactions table of common drugs and medications. Simvastatin is fdaapproved for the treatment of heterozygous familial hypercholesterolemia and is recommended for hyperlipidemia when either. Research has found that statin drugs can deplete the body of coenzyme q10, vitamin d and vitamin k2, which may contribute to statins common side effects. Handbook of fooddrug interactions nutrition assessment.
Atorvastatin interactions with food and herbs grapefruit and juice. Dec 11, 2014 many important interactions for simvastatin zocor and atorvastatin relate to drugs that inhibit or induce metabolism via the cytochrome p450 cyp3a4 enzyme, or that affect transport proteins. Simvastatin 80 mg is restricted to patients who have been taking simvastatin 80 mg chronically for example. Drug interactions of medications commonly used in diabetes. Dont learn the hard way which foods can prevent a prescription or overthecounter drug from working, or exacerbate. This interaction will lead to increased drug levels in the blood enhancing. Ask your doctor to check for potential interactions that simvastatin may have with any other medicines you take. Zocor simvastatin dose, indications, adverse effects. Statins are a class of drug prescribed for reducing blood cholesterol levels in individuals with high cholesterol. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Simvastatin is used along with a proper diet to help lower bad cholesterol and fats such as ldl, triglycerides and raise good cholesterol hdl in the blood. Mark this risk when a client is taking a drug or medication that can interfere with nutrient intake or use. Interactions between antihypertensive drugs and food.
Patients should avoid grapefruit entirely when on statins because it increases the side effects of the medication, oyeyipo says. Simvastatin is a, fda approved prescription medication that is used along with a proper diet to help lower bad cholesterol and fats such as ldl, triglycerides and raise good cholesterol in the blood. Simvastatin oral tablet is available as the brandname drug zocor. Simvastatin was most commonly prescribed and simvastatin drug coprescription predominated, especially at discharge. Approximately 22 million prescriptions are written in canada each year for statin drugs let that sink in for a minute. Give your doctor an uptodate list of all the medicines you take, including overthecounter medicines, herbal products, vitamins, and supplements. Do not take zocor if you are allergic to simvastatin or any ingredients contained in this drug. Some side effects may occur that usually do not need medical. There is no evidence of significant interaction when amlodipine is coadministered with atorvastatin, pitavastatin, rosuvastatin, fluvastatin, and pravastatin, and combination therapy may be considered. Food and drug administration fda is recommending limiting the use of the highest approved dose of the cholesterollowering medication, simvastatin 80. This table lists common drugs that can affect nutrition status. Eclectic medical publications, druginduced nutrient depletion handbook.
Handbook of drugnutrient interactions nutrition and. We look into the drug interactions by gender and age. There are 6 disease interactions with zocor simvastatin which include. In these cases, your doctor may want to change the dose, or other precautions may be necessary. This study is created by ehealthme based on reports of 652 people who take simvastatin and ranexa from the food and drug administration fda, and is updated regularly. This study is created by ehealthme based on reports of 7,009 people who take vitamin d and simvastatin from the food and drug administration fda, and is updated regularly. Statins are medications that work by reducing the amount of cholesterol made by the liver. Paritaprevir in fixeddose combination is predicted to increase the risk of rhabdomyolysis when given with simvastatin. In some cases, simvastatin drug interactions can cause your body to metabolize the medicines differently than intended, which can increase your risk of developing serious muscle problems, including myopathy and rhabdomyolysis. Ando h, tsuruoka s, yanagihara h, sugimoto k, miyata m, yamazoe y, takamura t, kaneko s. From the experts at healthnotes, this revised and updated edition contains the newest information on thousands of drugs and supplements, based on studies published in the leading medical journals. Nutrient drug interactions can occur with both prescription and overthecounter medicine. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal.
Drug interactions are reported among people who take simvastatin and cannabis together. Handbook of drug nutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for clinicians and students for many years to come. Consumer information for this interaction is not currently available. All of the 146 men and women in the study were determined to have low vitamin d levels less than 32ngml or. A food drug interaction may prevent a medicine form working the way it should, cause a side effect from a medicine to get worse or better. Coadministration with grapefruit juice may significantly increase the plasma concentrations of lovastatin and simvastatin and their active acid metabolites. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. This is a general list of medical conditions and medications that you should be aware of. Food drug interactions is a broader term that describes the effects of a drug on nutritional status. Common side effects are muscle pain, leg pain, vomiting, and stomach cramps. Jan 02, 2017 a 2015 study examined a group of individuals that were considered statin intolerant, meaning that they suffered from statin side effects, particularly muscle pains, that made it difficult or unbearable to continue taking the drug. Drug interaction with any of these substances may enhance or decrease the effect of simvastatin.
If you are taking drugs, you may need to avoid certain foods. Mar 18, 2020 statins are a class of drugs prescribed to lower ldl bad cholesterol. Drug interactions are reported among people who take simvastatin and ranexa together. Therapy usually is initiated with 10 or 20 mg daily, but individuals who have a high risk of heart disease can be started on 40 mg daily. In june 2011, the fda placed new labeling restrictions on simvastatin. If you are at high risk of heart disease, the starting dose is. Ezetimibesimvastatin and alcohol food interactions. Use of prescription or overthecounter drugs or medications shown to interfere with nutrient intake or use, to an extent that nutritional status is compromised. There are 496 drug interactions with zocor simvastatin zocor simvastatin disease interactions. The changes recommended against using 80mg doses of simvastatin, added 4 drugs to the list of contraindicated agents, and included several new simvastatin dose limitations when prescribed with drugs that inhibit its elimination.
Statins may, for example, raise blood levels of the clotpreventing drug warfarin, which could increase the risk of internal bleeding. Zocor tablets come in 5 milligrams mg, 10, 20, 40 and 80 mg. There is 1 alcoholfoodlifestyle interaction with simvastatin. Food and drug administration fda is notifying the public that it has revised the dose limitation for the cholesterollowering drug simvastatin. Food medication interactions 19th edition zaneta m pronsky ms rd ldn fada, dean elbe bsc pharm bcpp pharm d, laura finn bcgp fascp, william roberts md phd, keith ayoob edd rd fada, sol epstein md frcp facp on. The true incidence of drug interactions is unknown because many are not reported, do not result in significant harm to patients, or do not require admission to a hospital. Doses of simvastatin 10 mgd and doses of lovastatin 20 mgd when used with diltiazem or verapamil are not recommended. Be aware of potential drug drug interactions with simvastatin. As shown in tables 3 and 4 and as discussed below, we have surveyed the literature to identify reports suggesting important food and phytochemical modulation of drug metabolizing enzymes and drug transporters leading to potential important nutrient drug interactions. Drug and food interactions, effectiveness, and the safety of statins are provided. Simvastatin and ranexa drug interactions ehealthme.
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