Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. Derivation and validation of systemic lupus international. Correct classification of patients with systemic lupus erythematosus sle is critical for clinical trials and clinical and translational science. Systemic lupus erythematosus sle is a disease with an auto immune origin, which occurs nine times more often in women than in men, and. Slicc criteria for sle slicc classification criteria for. More than 90% of cases of sle occur in women, frequently starting at childbearing age. One is american college of rheumatology acr criteria first developed in 1982 and revised in 1997 1997 criteria 1, and the other is systemic lupus international collaborating clinics slicc criteria developed in 2012 2012 criteria 2. Diffuse thinning or hair fragility with visible broken hairs with positive pulling test or apparent alopecia convincing the patient to ask for physician consultation. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. The slicc criteria are more consistent with advancing concepts of sle, and they will exert substantial impact on clinical practice. The slicc criteria are validated criteria for making the diagnosis of lupus.
Terutama menyerang wanita usia reproduksi dengan angka. Use of slicc criteria in a large, diverse lupus registry enables sle. Performance of the new slicc classification criteria in childhood systemic lupus erythematosus. Creating a definition of systemic lupus erythematosus disease flare led by dr. The new 2019 eularacr classification criteria for sle requires a positive ana as obligatory entry criterion. May 02, 2019 to conclude, the recently proposed sle classification criteria from eular and acr and the 2012 slicc criteria showed comparable results regarding diagnostic sensitivity, specificity and accuracy using a scandinavian study population of confirmed sle cases and individuals with lupusmimicking conditions. A list of items that should be included in a damage index, with. Slicc criteria are very complexextended criteria and it can be. The slicc criteria have advanced the field and are absolutely right still.
The 2019 eularacr classification criteria for sle include positive ana at least once as obligatory en try criterion. Our aim was to validate the 2017 weighted criteria for pediatriconset sle. The use of slicc and acr criteria to correctly label. Objective sle is traditionally classified using the american college of rheumatology acr criteria. Pdf performance of the new slicc classification criteria. This performance was independently confirmed in the validation cohort. Clinical criteria acute cutaneous lupus or subacute cutaneous lupus.
Mar 18, 2020 systemic lupus erythematosus sle is a chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course. Background two major classification criteria have been used in the clinical trials of systemic lupus erythematosus sle. In 2017, the eular and acr joined in a fourphase project to. Eular and acr present sle classification criteria at the 2017 acr. Eular and acr present sle classification criteria at the 2017 acrarhp annual meeting. Lupus sering dijuluki dengan istilah great imitator atau penyakit seribu wajah. The criteria will now be validated against a large cohort. Nih funded networks accelerating medicines partnership clinical cohortsconsortiums lucin lupus clinical investigators network lrialr collaboration, repurposing drugs clinical trials outcomes research and new patient centered care delivery models. Validation of the systemic lupus international collaborating. Validation of the 2017 weighted criteria compared to the 1997. Criteria are cumulative and need not be present concurrently. The diagnostic accuracies of the 2012 slicc criteria and the proposed eularacr criteria for systemic lupus erythematosus classification are comparable. Diagnose patients with dementia with lewy bodies based on the 2017.
The diagnostic accuracies of the 2012 slicc criteria and the. In the slicc system, a patient must meet at least four criteria, including at least one abnormal clinical criterion and one abnormal. American college of rheumatology classification criteria for. The slicc criteria were validated by analysis of 690 patients with sle or other rheumatic diseases. Existing sle classification criteria perform better in patients with longstanding disease than in newonset sle 11, and there is an increasing recognition and demand that subjects with early. This systemic lupus diagnostic criteria slicc calculator helps the classification and diagnosis of sle based on clinical and immunological criteria. The 2012 slicc classification criteria for sle classify a patient as having sle if a the patient satisfies four of the criteria, including at least one clinical criterion and one immunologic criterion or. Diagnosis of dementia with lewy bodies dlb diagnose patients with dementia with lewy bodies based on the 2017 criteria diagnosis of multiple system atrophy. Dec 15, 2017 san diegothe proposed classification criteria for systemic lupus erythematosus sle, supported but not yet approved by the acr and eular, were debuted on nov. In an early sle cohort the acr1997, slicc 2012 and eular. Other criteria were chosen from 7 clinical constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal and 3 immunologic antiphospholipid antibodies, complement proteins, slespecific antibodies categories, and weighted from 2 to 10. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria and address concerns with the 1997 acr criteria. Sat0447 validation of the 2017 acreular classification.
Under the 2012 slicc criteria, patients have to be positive for antinuclear antibodies or antibodies to doublestranded dna, and lupus nephritis on histology means automatic sle classification. In the text below the form there is information on the slicc, along with instructions on how to interpret the criteria that is present. Eular and acr present sle classification criteria at the. The 32 patients without clinical sle less frequently ful. Op0020 validation of new systemic lupus erythematosus. Systemic lupus erythematosus, its treatment, and future.
Validation of the 2017 weighted criteria in pediatric. New eularacr classification criteria for sle rheumnow. Jul 14, 2014 both the acr revised criteria and the validated slicc criteria are designed for classification of patients for clinical studies and have not been tested for purposes of diagnosis. Sensitivity with these criteria is good, but specificity is below that of the acr criteria. Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Aug 25, 2017 under the 2012 slicc criteria, patients have to be positive for antinuclear antibodies or antibodies to doublestranded dna, and lupus nephritis on histology means automatic sle classification. Iraj salehiabari 2015, 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus. Evidence based medicine slicc criteria for sle cmi. Diagnosis and treatment of childhoodonset systemic lupus. However, they have become widely used as diagnostic criteria in clinical situations. In this initial validation testing, the slicc revised criteria had greater sensitivity but lower specificity than the 1997 acr classification criteria sensitivity of 97 versus 83 percent and specificity of 84 versus 96 percent, respectively. Nov 05, 2017 eular and acr present sle classification criteria at the 2017 acrarhp annual meeting. The systemic lupus international cooperating clinics slicc 2012 criteria increased sensitivity, but at the price of reduced specificity.
Systemic lupus diagnostic criteria slicc calculator. Terinspirasi dari pertemuan penyusunan petunjuk teknis pengendalian sle yang difasilitasi oleh kemenkes, dan saya bersama tim syamsi dhuha bandunng, ada ilmu yang sangat bagus yang bisa saya sharing. Use of slicc criteria in a large, diverse lupus registry. Slicc classification criteria for sle current medical. The recent used diagnostic criteria widely used for sle is 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Eular and acr present sle classification criteria at the 2017.
Jun 22, 2018 the new criteria allow for a shift in the way we think of the disease. Validation of the systemic lupus international collaborating clinics. A multicentre study article pdf available in clinical and experimental rheumatology 323 march. San diegothe proposed classification criteria for systemic lupus erythematosus sle, supported but not yet approved by the acr and eular, were debuted on nov. At first visit, slicc criteria had higher sensitivity than acr 1997 89. Pdf performance of the new slicc classification criteria in. In 2017, weighted criteria were proposed that included entry criteria, something the 1997 and the 2012 criteria did not identify. Clinics slicc 2012 criteria were more sensitive than the american college of rheumatology acr 1997 criteria in reallife systemic lupus erythematosus sle clinical practice. This study aims to compare the performance among the american college of rheumatology acr 1997, the systemic lupus international collaborating clinics criteria slicc and the new european league against rheumatism eularacr criteria, in a csle cohort. After ranking and scoring by a different expert panel, the criteria were tested in a derivation cohort and found to have a sensitivity of 98% and a specificity of 97%higher than both the 1997 acr and 2012 slicc criteria, she said. Development of the slicc classification criteria for systemic lupus erythematosus in 2012 led by dr. Patients may be labelled as systemic lupus erythematosus sle in their medical records, when in fact they have. Isenberg ongoing research currently, slicc members are engaged in several ongoing areas of key focus.
Pdf 2015 acrslicc revised criteria for diagnosis of systemic. In 2017, a weighted criteria were proposed at the acr meeting. The diagnostic accuracies of the 2012 slicc criteria and. Acute cutaneous lupus, including lupus malar rash, bullous lupus, toxic epidermal necrolysis variant of systemic lupus erythematosus, photosensitive lupus rash, maculopapular lupus rash, or subacute cutaneous lupus psoriaform or annular polycyclic lesions or both 2. Comparison among acr1997, slicc and the new eularacr. Pdf 2015 acrslicc revised criteria for diagnosis of. An online calculator can be used to calculate the slicc score. Results the criteria were finetuned and simplified, using ana of. This study examined large cohorts of subjects with sle and incomplete lupus erythematosus ile to compare the impact of acr and slicc criteria. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially.
In 2017, the eular and acr joined in a fourphase project to develop more sensitive especially for initial classification and more specific sle. Regular exercise and stress make a big difference in lupus %mouse model of lupus. Both the acr revised criteria and the validated slicc criteria are designed for classification of patients for clinical studies and have not been tested for purposes of diagnosis. New classification system for systemic lupus erythematosus. We have now compared both sets of criteria in a wellcharacterized sle cohort. Remember, these are classification criteria and not diagnostic criteria and failure to meet the criteria does not exclude csle. To conclude, the recently proposed sle classification criteria from eular and acr and the 2012 slicc criteria showed comparable results regarding diagnostic sensitivity, specificity and accuracy using a scandinavian study population of confirmed sle cases and individuals with lupusmimicking conditions. The 2012 revised slicc criteria for classification of. Pathogenesis 20 and clinical features 1 introduction. The criteria do not need to occur simultaneously and may have occurred over a number of monthsyears see cases, box 4. Validation of new systemic lupus erythematosus classification. New understandings of sle pathogenesis have rendered the 1982 acr criteria outdated, according to a recently published paper arthritis care res.
The slicc group has proposed a modification of the revisedupdated sle acr classification criteria. There are currently two classification criteria in use. American college of rheumatology guidelines for screening, treatment, and management of lupus nephritis bevra h. An international steering committee developed and validated the criteria, with patient input and the consensus of more than 150 global sle experts. Validation of the 2017 weighted criteria compared to the. In an early sle cohort the acr1997, slicc 2012 and eularacr2019 criteria classify nonoverlapping groups of patients. Slicc classification criteria for systemic lupus erythematosus. Slicc 12 criteria are more effectiveness than acr 97 score.
The new criteria allow for a shift in the way we think of the disease. The slicc criteria for sle classification requires. Slicc criteria for sle slicc classification criteria for sle. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria. The american college of rheumatology acr classification criteria for lupus and systemic lupus international collaborating clinics slicc criteria are designed to classify disease. Pdf on apr 20, 2015, iraj salehi abari and others published 2015 acrslicc. The acr 1997 criteria were criticized for their suboptimal sensitivity.
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